Home > Browse Issues > Vol.26 No.4
Cell DNA Damage Checkpoint
Xiao-Jing Yu1,2, Jia-Wei Zhou1*, Chong-Gang Yuan2*
1Key Laboratory of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; 2School of Life Science, East China Normal University, Shang
Abstract: Tissue transglutaminase (tTG) is one of members of transglutaminase family. It is believed to be a multifunctional protein， which can catalyze cross-linking of protein and hydrolyzation of GTP and ATP. Furthermore， tTG can function as Gah in Ca2+-associated signal pathway. It has been reported that tTG is involved in a broad range of biological processes such as cell growth and differentiation， receptor-mediated endocytosis， cell adhesion， maintenance of cell morphology and inducement of apoptosis. Recently， it has been suggested that tTG may play important roles in pathogenesis of neurodegenerative diseases， such as Alzheimer''s disease， Parkinson''s disease， Huntington''s disease. Some recent progress on the involvement of tTG in these diseases will be presented in this review.
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