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Advancement in Estrogen and Estrogen Receptor Signaling
TAN Yin Fei, WANG Yan Ling*
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China
Abstract: The classical signaling pathway of estrogen receptor (ER) is the ligand-dependent one which involves ERα and ERβ that belong to the classical nuclear steroid/thyroid receptor superfamily. Recent studies demonstrate that ER can also be activated through the crosstalk with other signaling pathways in estrogen-dependent or -independent manners. In addition， ER is involved in the regulation of cell proliferation by multiple interactions with other transcriptional factors to modulate their transcriptional activation. Furthermore， a cell surface form of ER can mediate rapid response of vascular endothelial cell to estrogen.
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