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The Roles of GTPase Ran in Nuclear Processes throughout the Cell Cycle
FENG Dong Ru, WANG Jin Fa*
The Key Laboratory of Gene Engineering of Ministry of Education, School of Life Sciences, Sun Yat-sen(Zhongshan)University, Guangzhou 510275, China
Abstract: The small monomeric G protein Ran has GTPase activity， its bound conformation Ran-GTP might act as a molecular marker that distinguishes the nucleoplasm from the cytoplasm of interphase cells， and plays different roles in nucleocytoplasmic transport， mitotic spindle assembly and nuclear envelope dynamics. This paper reviewed the roles of GTPase Ran in nucleocytoplasmic transport， nuclear division and reestablishment throughout the cell cycle.
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