Home > Browse Issues > Vol.26 No.2
Endoplasmic Reticulum-associated Proteins Degradation
QI Jing, PENG Jian Xin1*
College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430072, China; 1College of Life Science, Central China Normal University, Wuhan 430079, China
Abstract: Endoplasmic retimulum-associated protein degradation (ERAD) is an important pathway for proteins quality control in eukaryotic cells. ERAD undertakes the identification， sorting and degradation of malfolded proteins or aberrant proteins to prevent toxification by the accumulation of misfloded proteins in ER. ERAD mainly includes three-step process: the first is the recognition of aberrant or malfolded ER proteins， in second step， degradation substrates are retrograde transported from the ER back into the cytoplasm， in the final step， aberrant proteins are degraded by the cytosolic ubiquitin/ proteasome pathway. Some human diseases closely link ERAD and certain viruses are able to exploit the host ERAD machinery to escape the immune surveillance and attacking.
CN
EN