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Research Advances on Function of PLC-γ
ZHANG Bing1, 2, WU Qiao1*
1Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen university; 2 Medical School, Xiamen University; Xiamen 361005, China
Abstract: Phospholipase C-γ is rapidly activated in response to the activation of more than 100 different cell surface receptors by two different mechanisms， and catalyzes the hydrolysis of phosphatidylinositol 4， 5-bisphoaphate to inositol 1， 4， 5-trisphosphate and diacylglycerol. They mediate intracellular Ca2+ release and the activation of protein kinase C(PKC)， respectively. This bifurcating pathway constitutes the cornerstone of a transmembrane signal transduction mechanism that is now know to regulate cell cycle， cell transformation， development， apoptosis of cell， and control actin cytoskeleton. Phospholipase C-γ has a wide crosstalk with the other pathways， for example， PKC， Ras， Ca2+ pathway et al.. Then， Phospholipase C-γ plays a important role in the metabolize of cell.
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