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Diploid-tetraploid Chimera Mouse and Its Applications in the Study of Gene Function
1Shanghai Transgenic Research Center, Shanghai 201203, China; 2Research and Teaching Institute of Cell Biology, Department of Basic Medicines, Second Military Medical University, Shanghai 200433, China
Abstract: As a specific type of rescuing chimerism， diploid-tetraploid aggregation approach usually results in pure animals derived predomintly from diploid component， which fulfills its wide application in gene expression and control research. This review hereby summerizes current diploid-tetraploid research progresses and its possible applications in gene function， meanwhile， the relevant prospective has also been envisaged objectively.
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