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Radiosensitivity of CNE1 and CNE2 Cell Lines Induced by Cisplatin
Hai Sun, Fa-Quan Liu1, Ju-Yi Wen, Man-Ming Cao, Peng Li, Ji-Ren Zhang*
Oncology Center, Zhujiang Hospital, Nanfang Medical University, Guangzhou 510280, China;1Oncology Department, the Second People's Hospital of Guangdong Province, Guangzhou 510317, China
Abstract: To study the relationship between radiosensitivity and multidrug resistance expression of CNE1 and CNE2 cell lines， CNE1 and CNE2 cell lines were induced by gradually enhanced density cisplatin， and reversal multiple of cyclosporine A and interferon using alone or together were analysised with MTT colorimetric assay ， and the radiosensitivity differentiation of multidrug resistance cell lines before and after reversed with cyclosporine A and interferon were analysised with clone formation experiment， and the effection of cyclosporine A and interferon on radiosensitivity were analysised at the same time. The results showed that reversal multiple of cyclosporine A united with interferon was stronger obviously than that of cyclosporine A or interferon applied alone. Radiosensitivity of CNE1 cell line showed no change after induced with cisplatin， and that of CNE2 cell line was downregulated after induced with cisplatin， and cyclosporine A and interferon could reverse it's radiosensitivity partly.
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