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CED-9 and Its Regulation Mechanism in Programmed Cell Death
Hong-Hong Shao, Ke Zheng, Wen-Zhe Wang, Ilham Ahmat, Mu-Yuan Zhu*
College of Life Sciences, Zhejiang University, Hangzhou 310012,China
Abstract: Programmed cell death is an essential process for development and homeostasis in both animal and plant. In the nematode C. elegans， CED-9， an anti-apoptosis member of the Bcl-2 family， plays critical roles in the induction and execution of the death pathway. Expression of CED-9 targets CED-4 from the cytosol to intracellular membranes， releasing CED-3 caspase to suppress apoptosis. The binding of EGL-1 to CED-9 induces a drastic rearrangement of the structure of CED-9， and thus destabilizes the CED-4/CED-9 complex， leading to cell death. This review introduces the unique structure characteristic and working model of CED-9， and discusses its function and possible mechanism in transgene plants and yeast.
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