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Antigenic Peptides Bound to MHC Class I Molecule
Xiao -Wen Lü, Fei-Jie Lü Jing Wang1
Institute of Feed Science, Chinese Academy of Agricultural Sciences, Beijing 100081, China;1College of Life Science, Peking University, Beijing 100083, China
Abstract: the antigenic peptide binding with major histocompatibility complex ( MHC ) class I molecules at the cell surface directly reflect the changing of protein in the cell， the antigenic peptide advance the assembly and export of MHC class I complex in ER， and stable the association of MHC class I complex and TCR; the antigenic peptide is partly from the degradation of new synthetic endogenous proteins by proteasome and some peptidases， the characteristics of the peptide transporter associated with antigen processing (TAP) modulate the specificity of the antigenic， as well as MHC class I molecule.
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