Home > Browse Issues > Vol.27 No.6
P-Selectin Glycoprotein Ligand 1 and the Initial Adhesion of Leukocyte
Lin Chen, Xue-Qing Ba1*
Central Blood Station of Changchun, Changchun 130033, China; 1Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, China
Abstract: P-selectin glycoprotein ligand 1 (PSGL-1) was found at the beginning of 1990s? It is a transmembrane glycoprotein with homodimeric structure and expresses on the surface of almost all leukocytes. PSGL-1 is the best-characterized selectin ligand to date. PSGL-1 was isolated through affinity chromatography by using P-selectin as a probe， and shows high affinity to P-selectin. The accumulating data further demonstrate that PSGL-1 also acts as the physiological ligand of L-selectin and E-selectin. The reaction of PSGL-1 with selectins initiates the rolling adhesion of leukocytes on the endothelium cells， which lead to the maximum activation and firm adhesion of leukocytes. The present review summarized the studies on PSGL-1's structure， localization， expressional regulation， signal transduction， physiological and pathological role and clinical therapeutics in the decade.
CN
EN