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Regulation of Ovarian Function by cGMP
Zhen-Qi Zhou, Ling-Mei Pan, Tian Wang*, Fang-Xiong Shi*
College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
Abstract: Cyclic guanosine monophosphate (cGMP) as one kind of cyclic nucleotides， plays important roles in various physiological processes. It was known that cGMP， as a second messenger， had a potential role in modulating ovarian functions in 1980s. However， the role of cGMP modulating ovarian functions has received considerably less attention. Ovary is an important organ in the female animal， and cGMP regulates a wide range of ovarian functions. This report reviews the production of cGMP， the inhibitory effect of cGMP on ovarian estradiol production， LH receptor expression and follicular atresia， and the mechanism of cGMP signalling.
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