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CHP2 Regulates the Activity of NHE1 Reducing Cell Death upon to Serum Depletion
Qing-Hua Li, Tian-Xiang Pang*, Wen-Su Yuan, Zhong-Chao Han
Union Stem Cell & Gene Engineering Co., Ltd., State Key Laboratory of Experimental Hematology, Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China
Abstract: The Na+/H+ exchanger (NHE) is a main protein to maintain the intracellular pH (pHi). Calcineurin B homologous protein (CHP) is an essential regulation cofactor for NHE. Under the condition of serum depletion in PS120 cells， CHP2 can regulate the activity of NHE1， maintain the essential physiology activity of NHE1， promote the intracellular pH to a high level (pHi 7.4). CHP2 also can reduce the cell death caused by self-acidification of cytoplasm and prolong time of cell survival after long serum starvation (70% cells can survive more than 7 days). The results indicated that by means of reducing the expression of CHP2 or repressing its activity， we may get new methods to promote cell death.
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