Home > Browse Issues > Vol.27 No.5
Protection of Telomere 1
Wei-Guo Li*, Kun-Ying Wang
College of Life Sciences, Henan Normal University, Xinxiang 453007, China
Abstract: Protection of telomere 1 (POT1) is a single-stranded telomeric DNA binding protein identified in fission yeast and human， which binds specifically to the G-rich telomere strand. Human POT1 gene contains 22 exons， four of which are subject to exon skipping in some transcripts， giving rise to five splice variants. POT1 is proposed not only to participate in telomere maintenance， but also to recruit telomerase to the ends of chromosomes. POT1 plays functions in telomere maintenance and stability， through TRF1-TIN2-PTOP-POT1 pathway on control of telomere length by telomerase.
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