Regulation of Tumor Suppressors Hamartin and Tuberin Signaling

Abstract: Tuberous sclerosis is an autosomal dominant disorder caused by mutations in tsc1 and tsc2 genes. Hamartin and tuberin， encoded by tsc1 and tsc2 genes， respectively， are tumor suppressors and play critical roles in cell growth and proliferation. Growth factor-stimulated PI3K/Akt signaling leads to tuberin phosphorylation， then regulates downstream effector function and affects cell growth and proliferation. This review summarizes the latest progresses in hamartin-and tuberin-mediated signaling transduction. We hope this review will give some insights into the understanding of the roles of hamartin and tuberin in cellular signaling and the challenge behind them.

CSTR: 32200.14.cjcb.2005.05.0003