Home > Browse Issues > Vol.27 No.5
The HB-EGF and Its Expression and Function in the Malignant Blood Cells
Xiang-Fei Yuan, Min Lu*
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China
Abstract: HB-EGF is a member of EGF family， which is expressed in various tissues and cells， and involves in many pathologic and physiological processes. ProHB-EGF and its products of cleavage including sHB-EGF and HB-EGF-C play roles in the proliferation and migration. However， there have been few reports about the relationship between the HB-EGF and malignant blood cells because of the low levels expressions of HB-EGF and its receptors. Recent studies have confirmed the expression of HB-EGF in myeloma and leukemia cells. HB-EGF has the potency of inducing these cells to proliferate， but unfortunately， the mechanisms are unclear. Understanding of these mechanisms is essential in order to develop new methods to treat leukemia and myeloma.
CN
EN