Home > Browse Issues > Vol.27 No.5
Cell Cycle Checkpoints
Qiu-Feng Cai, Rui-Sheng Jiang, Gao-Liang Ouyang*, Shi-Deng Bao
The Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China
Abstract: Cell cycle is a collection of highly ordered processes which are regulated by DNA damage checkpoint， DNA replication checkpoint and spindle checkpoint. Cell cycle checkpoints control the order and timing of cell cycle transitions and ensure that critical events such as DNA replication and chromosome segregation are completed with high fidelity. In addition， cell cycle checkpoints respond to DNA damage， DNA replication blocks， abnormal spindle assembly and improper chromosome segregation by inducing transcription of genes that facilitate repair to avoid mutations and genetic instability. Cell cycle checkpoints loss will result in genomic instability and cell carcinogenesis. Therefore， cell cycle checkpoints play a vital role in maintaining genomic stability and avoiding cell carcinogenesis and many genetic diseases.
CN
EN