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Eukaryotic mRNA Transcriptional Termination Mechanism
Xiao-Qiang Guo*, Jiang-Yan Wang, Ren-Jie Wang
Department of Biochemistry, Bethune Military Medical College, Shijiazhuang 050081, China
Abstract: Transcription of eukaryotic mRNA by RNA polymerase II (PolII) is an essential step in gene expression， but its termination is poorly understood. Many experiments showed that mRNA transcriptional termination was involved in the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II， several transcriptional termination related factors and their interaction. These results roughly draw the general outline of eukaryotic mRNA transcriptional termination.
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