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The Anti-cancer Mechanism and Influence Factors of Photodynamic Therapy
Shen-Feng Zhang, Xing-Guo Gong*
College of Life Sciences, Zhejiang University, Hangzhou 310027, China
Abstract: It has been more than 25 years since photodynamic therapy (PDT) was proposed as a useful tool in oncology， but the approach is only now being used more widely in the clinic. Several photosensitising drugs have now been approved for clinical use in some countries. Studies about the new photosensitizers' synthesis， action mechanism and trials in vitro/in vivo have been developed rapidly and have achieved a lot in recent years. Here， based on the basic photodynamic principle， The article reviewed latest achievements in the study of anti-cancer mechanism especially in cell level and influence factors of PDT. The deeper understanding in the mechanism of PDT will help us to look for new ways， which can enhance the efficacy of PDT and push PDT to be a mainstream therapy in near future.
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