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Mitogen-activated Protein Kinase Phosphatase
Bao-Qing Xu, Ji-Xi Li, Xing-Guo Gong*
College of Life Sciences, Zhejiang University, Hangzhou 310027, China
Abstract: Mitogen-activated protein kinase phosphatases (MKPs)， including both dual-specificity (threonine/tyrosine) and tyrosine-specific enzymes， play a key role in the process of cell proliferation， differentiation， and gene expression. MKPs can selectively bind to mitogen activated protein kinases (MAPKs)， and therefore regulate the activity of MAPK-mediated signal pathway by dephosphating MAPKs. On the other hand， MAPKs can also activate MKPs. The interactions between MKPs and MAPKs insure the exactly signal transduction in cells
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