Home > Browse Issues > Vol.27 No.4
Nucleocytoplasmic Shuttling of Nuclear Receptors and Regulatory Mechanisms
Xiao-Feng Lin, Qiao Wu*
Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences,
Abstract: Nuclear receptors， which belong to nuclear transcriptional factors， not only translocate into the nucleus rapidly after synthesized in the cytoplasm， but also shuttle between the cytoplasm and the nucleus to exert their specifically biological functions. Nucleocytoplasmic shuttling of nuclear receptor relies on the nuclear pore complexes， the transport carriers (including Importins and Exportins) and the energy pool-Ran-GDP. Here， we summarize the current research progresses on nucleocytoplasmic shuttlling of nuclear receptors (including GR， AR， ER) and their regulatory mechanisms. In addition， we also introduce a novel function of RXRα in its nucleocytoplasmic shuttling found by our laboratory.
CN
EN