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Expression of β-TrCP and β-catenin in Mice Endometria during Embryo Implantation
Jing Huang1,2, Jun-Lin He1,2, Xue-Qing Liu1,2, Yu-Bin Ding1,2, Shi-Zhi Chen1,2, Xue-Mei Chen1,2, Ying-Xiong Wang1,2*
1Laboratory of Reproductive Biology, Chongqing Medical University, Chongqing 400016, China;2Department of Genetics, Chongqing Medical University, Chongqing 400016, China
Abstract: In order to investigate the potential role of β-transducin repeat-containing protein (β-TrCP) during early pregnancy， the mouse models of early pregnancy and pseudopregnancy were established respectively， then the endometria at different stages were collected. The distribution and expression level of β-TrCP and β-catenin of each stage were examined by RT-PCR， Western blotting， immunohistochemistry respectively. The spatio-temporal differences of expression of β-TrCP and b-catenin in mice endometria during early pregnancy were shown. The expression level of β-TrCP and β-catenin reached a maximum and minimum on the fourth day of pregnancy (the window of implantation) respectively. So we suggest that β-TrCP might participate in molecules cross-talk and signal transduction during implantation through mediating the ubiquitination and degradation of β-catenin which is a key mediator of the Wnt pathway and promote embryo implantation.
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