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Sertoli-Sertoli Tight Junction and Male Contraceptive
De-Yu Chen1,2, Yu-Feng Huang1*
1 Laboratory of Reproduction and Genetics, Nanjing General Hospital of Nanjing Command, People's Liberation Army, Nanjing 210002, China; 2Department of Biology, Fuyang Normal College, Fuyang 230632, China
Abstract: In this review， we discuss the physiology and biology of Sertoli-Sertoli junction dynamics in the testis， in particular how these events affect interactions of Sertoli and germ cells in the seminiferous epithelium behind the blood-testis barrier. We also discuss how these events regulate the opening and closing of the blood-testis barrier to permit the timely passage of preleptotene and leptotene spermatocytes across the blood-testis barrier. We also discuss several available in vitro and in vivo models that can be used to study Sertoli-Sertoli tight junction. An in-depth survey in this subject has also identified several potential targets to be tackled to perturb spermatogenesis， which will likely lead to the development of novel male contraceptives.
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