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Quantitative Proteomics Using Isotope Labeling Techniques and Its Recent Application
Xiao-Hui Long, Yao-Zhou Zhang1*
College of Life Science, Zhejiang University, Hangzhou 310029, China; 1College of Life Science, Zhejiang University of Science and Technology, Hangzhou 310018, China
Abstract: Quantitative proteomics is defined as the systematic identification and the determination of quantitative change in the complete proteome. Quantitative proteomics focus on the information of dynamical changes of proteins of complex samples， and is expected to provide new functional insights into the processes of biological systems. The use of stable isotopes as internal standards in mass spectrometry has opened a new era for quantitative proteomics and has the potential for studying on proteins by identifying and quantifying automatically and simultaneously. Advance in isotope labeling techniques and recent biological applications are reviewed， further development based on quantitative proteomics is discussed.
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