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Ubiquitin Ligase E3
Dong-Ye Yang, Kai-Yu Liu, Ze-Hua Yu*
Institute of Entomology, Central China Normal University, Wuhan 430079, Chi
Abstract: Ubiquitination of protein is high selective and very important in regulating various cellular processes. Ubiquitination involves the successive actions of the ubiquin-activating enzyme(E1)， ubiquitin-conjugating enzyme(E2)， and ubiquitin-protein ligase enzyme(E3). E3 is most directly responsible for substrate recognization. It contains three members， including HECT domain E3， RING domain E3， and U-box domain E3. Here， we summarize the classification， the structure and the mechanism of substrate recognization of ubiquitin-protein ligase enzyme (E3).
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