Advance in Mitochondrial Complex I Mediated Movement Prevention and Treatment of Parkinson’s Disease
ZHOU Wenhui*, SUN Jie, LONG Gang
PD (Parkinson’s disease) is the second most common neurodegenerative disease worldwide and seriously affects patients’ daily life. MCI (mitochondrial complex I) is a core component of the mitochondrial ETC (electron transport chain), and its dysfunction is closely related to the pathogenesis of PD. Therapies that targeted MCI dysfunction may be an effective strategy to delay the progression of PD. Exercise can effectively delay the progression of different diseases and improve daily life function and related behavioral dysfunction, and one of the mechanisms may be mediated by up-regulating MCI expression levels. Therefore, this article reviews the role of MCI on the pathogenesis and treatment of PD, with a focus on the mechanisms through which exercise may confer protection against PD via MCI.
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