Metabolic Oscillations in Tumors: Glycolysis, Calcium Ions, and cAMP
ZHANG Liuyu, ZHANG Shuo, WAN Fang*
Biological metabolic oscillations are a common phenomenon in life activities and play a crucial role in cellular metabolic regulation. In recent years, although biological metabolic oscillations have gained increasing attention in scientific research, a comprehensive review and systematic summary of this field remain insufficient. This article reviews the basic principles of biological metabolic oscillations, as well as glycolysis, calcium ion, and cAMP oscillations in tumors. In tumor cells, glycolysis oscillations meet energy demands, Ca2+ oscillations regulate cell pro liferation, and cAMP and ROS (reactive oxygen species) oscillations interact with these processes in complex ways. Neurons participate in tumor progression by interacting with oscillation signals. These findings provide new insights into the mechanisms of tumor development and the development of therapies targeting metabolic oscillations. The ar ticle summarizes recent discoveries in metabolic oscillations and provides information on understanding this fascinat ing phenomenon by analyzing the interactions among four types of metabolic oscillations.
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