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CD4+CD25+ Regulatory T Cells
Sheng-Jun Wang1,2*, Hua-Xi Xu1, Sheng-Li Yang2
1Department of Immunology, School of Medical Technology, Jiangsu University, Zhenjiang 212001, China; 2Life Science Institute, Jiangsu University, Zhenjiang 212013, China
Abstract: Thymus derived CD4+CD25+ regulatory T cells (Treg) were critical for the inhibition of autoreactive T cells and play a crucial role in maintaining self-tolerance. These cells mediated their suppressive effects by direct cell to cell contact-dependent， without the requirement of immunosuppressive cytokines. There were more evidences that the transcription factor Foxp3 acted as the "master control gene" for Treg that defined this subset as a distinct T cell lineage. Regulatory T cells were produced by immunosuppressive cytokines， such as interleukin-10 or TGF-β， and immature dendritic cells. A better understanding of the role of regulatory T cells in autoimmunity and anti-tumor immunity may lead to the identification of novel therapeutic targets.
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