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Thrombin and Vascular Endothelial Cell
Min Wang*, Xiao-Jun Wang1, Lian-Qun Cui1
Department of Biomedicine, College of Informational and Electrical Engineering , Shandong University of Science and Technology , Jinan 250031, China; 1Department of Cardiology, Shangdong Provincial Hospital, the Clinical Medical Colleage of Sha
Abstract: Thrombin plays an important role in blood coagulation. Thrombin also exerts direct effects on vascular cells， which interacts with members of the protease-activated receptor family. Evidences implicate thrombin-mediated signaling events in the response to injury that typifies vascular lesion formation in atherosclerosis and restenosis. In this review， we focus on that thrombin signaling in the endothelium is linked to multiple changes， including alterations in permeability， expression of matrix metalloproteinases， vascular endothelial growth factor and adhesion molecules.
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