Progress of Effects of VDAC1 in Central Nervous System Diseases and Its Mechanism
ZHOU Juanping, BAO Lijuan, ZHANG Tianjiao, REN Taowen*
Central nervous system diseases include neurodegenerative diseases, cerebrovascular diseases, etc., in which mitochondrial dysfunction plays an important role. VDAC1 (voltage-dependent anion channel 1) is a channel protein on the outer membrane of mitochondria that is involved in the exchange of metabolic products and ions between the cytoplasm and mitochondria, cellular energy metabolism, Ca2+ homeostasis, and mediating apoptosis through the mitochondrial pathway. More and more studies have shown that VDAC1 is involved in the pathophysiological processes of multiple central nervous system diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis and stroke. This review summarizes the current role of VDAC1 in central nervous system diseases, focusing on the interaction between VDAC1 and disease-specific proteins (such as β-amyloid, phosphorylated tau, and α-synuclein), and explores potential treatment strategies targeting VDAC1.
CN
EN