Home > Browse Issues > Vol.27 No.1
Progress in RTNs Family
Yi-Cun Chen, Dong-Dong Lu, Xi-Ran Zhang*
The College of Life Science, Nanjing Normal University, The Jiangsu Key Laboratory of Molecular and Medical Biotechnology , Nanjing 210097,China
Abstract: Reticulons (RTNs) were an eukaryotic gene family with peculiar topological features and broad expressions. RTNs were characterized by a ～200-amino-acid C-terminal domain， including two long hydrophobic sequences. RTNs functions might relate to those of the endoplasmic reticulum —for example， intracellular trafficking， cell division and apoptosis. Nogo/RTN4-A could inhibit neurite growth from the cell surface via specific receptors. Here， we reviewed the basic structure， the taxonomic distribution and tissue expression of RTNs， summarized recent discoveries about RTNs localization and membrane topology， and discussed the possible functions of RTNs.
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