Research Progress of Plant Extracellular Vesicles in Tumor Disease
MA Wenyan1,2, XIN Jie1,2, MIAO Yuhang1,2, DING Tao1,2, ZHOU Xuezhang1,2*, DU Jun1,2*
PEVs (plant extracellular vesicles) are nanoscale bilayer vesicles spontaneously secreted by living plant cells. PEVs encapsulate lipids, proteins, nucleic acid and many other biological information molecules. It can be used as a therapeutic agent to play an anti-tumor role by inhibiting tumor microenvironment, regulating tumor metabolism, inhibiting tumor cell proliferation and metastasis, promoting tumor cell apoptosis, inhibiting angiogenesis of tumor cells, reducing drug resistance, regulating the intestinal flora and inhibiting inflammatory responses in various ways. It can also be used as a drug carrier to deliver small molecules, nucleic acids and proteins anti-tumor drugs to play a synergistic role in the treatment of tumor diseases and improve the therapeutic effect. In this paper, the biogenesis, separation methods and component analysis of PEVs, and the research progress of PEVs as drugs and carriers in tumor diseases are summarized in detail, in order to provide theoretical reference for the research of PEVs in the field of tumor diseases and promote its practical application in the treatment of tumor diseases.
CN
EN