Advances in the Mechanisms of Unfolded Protein Response-Regulated Osteoblast Apoptosis in Osteoporosis
LI Tong, TANG Sha, CUI Hongwang*
Osteoporosis, a metabolic bone disease impacting the elderly, is marked by reduced bone density and structural damage. Despite novel treatments, drug efficacy and side effects pose clinical challenges, making research into new medications crucial. Endoplasmic reticulum stress triggers three downstream pathways via the unfolded protein response to affect osteoblast survival. However, overactivation of signaling pathways in the unfolded protein response can induce osteoblast apoptosis. Suppressing this overactivation is key to reducing osteoblast apoptosis. Consequently, this article reviews the progress of unfolded protein response-mediated osteoblast apoptosis regulation in osteoporosis-related diseases, aiming to offer new insights for osteoporosis treatment and research.
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