Research Progress on the Intervention of Aerobic Exercise on Microvascular Function in Tumor Tissues
LIU Qi1, ZHU Huan1*, WANG Kangfeng2, FU Beilun1, LI Miao1, ZHOU Shufeng1, HU Jiangping2
Aerobic exercise, as an important auxiliary treatment for tumor diseases, has been widely applied in clinical practice. Most studies have revealed that aerobic exercise exerts therapeutic effects by promoting the “normalization of tumor microvascular function”. However, some studies have pointed out that exercise cannot effectively improve the microvascular function of tumor tissues. These differing results may stem from factors such as exercise time and exercise intensity. Based on this, this study will review the intervention effects of exercise on the microvasculature of tumor tissues from the perspectives of exercise time and exercise intensity, providing theoretical basis and exercise program references for improving the microvascular function of tumor tissues. Studies have shown that the main characteristics of microvascular function in tumor tissues are abnormal increase in microvascular density and poor microvascular blood perfusion, which leads to hypoxia in tumor tissues. For the microvascular dysfunction of tumor tissues, both single (5-30 min) and regimens lasting 2-8 weeks (3-5 times/week) of moderate to low-intensity aerobic exercise can improve the microvascular function of tumor tissues. In addition, exercise mainly improves microvascular function by regulating the levels of related factors in the tumor microenvironment and increasing the laminar shear stress acting on the surface of microvascular endothelial cells.
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