Advances in Mitochondrial Regulation of Aging-Related Secretory Phenotypes

KONG Zhengyi¹, LI Chujun¹, YAN Qingfeng^1,2,3,4*

(¹College of Life Sciences, Zhejiang University, Hangzhou 310058, China; ²The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; ³Zhejiang Key Laboratory of Cell and Molecular Intelligence Design and Development Applications, Hangzhou 310058, China; ⁴Zhejiang University-Lishui Joint Innovation Center for Life and Health, Lishui 323000, China)

Abstract:

Aging is the irreversible process of functional decline and loss in the body, and senescence is a key driving factor for aging. The aging related secretory phenotype is an important characteristic of senescence, which affects the communication between surrounding cells through paracrine secretion into the tissue microenvironment, resulting in various physiological and pathological effects. Mitochondria are closely related to the secretory phenotype associated with aging, and the two are closely interconnected through a network of interrelated signaling pathways. On the basis of a brief introduction to the characteristics of cellular aging and aging related secretory phenotypes, this article provides a detailed review of the mechanisms and research progress of regulating aging related secretory phenotypes, such as mitochondrial reactive oxygen species, mitochondrial metabolic abnormalities, and mitochondrial DNA release. It also explores the possible problems and prospects in related fields.

CSTR: 32200.14.cjcb.2025.08.0025