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The Activation and Function of p38 MAPK Signal Transduction Pathway in Articular Chondrocytes
Xian-Bo Wang, Qing Jiang*
The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China
Abstract: The p38 signalling transduction pathway， a mitogen-activated protein kinase (MAPK) pathway， in chondrocytes， is activated when exposed to a variety of stimuli including of cytokines and mechanical factor. Studies have revealed that activation of the p38 pathway is related to many physiological and pathological changes in chondrocytes， such as differentiation， hypertrophy， ossification， apoptosis， synthesis of proinflammatory cytokines and matrix metalloproteinases. The p38 pathway may play an essential role in the development of arthritis.
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