Progress in the Effect of JNK in the Prevention and Treatment of Parkinson’s Disease by Exercise
YOU Shuxian1, ZHOU Wenhui1*, LI Gangqiang2
PD (Parkinson’s disease) is a multifactorial neurodegenerative disease involving different pathological processes. Dysregulation of JNK (c-Jun N-terminal kinase) signaling pathway is involved in the pathogenesis of PD. The inhibition of JNK activity has been proposed as a novel therapeutic strategy for PD. Exercise can reduce the incidence of PD and relieve PD motor and non-motor symptoms, and it can also inhibit JNK activity, suggesting that JNK may serve as a potential molecular target for exercise-mediated prevention and treatment of PD. This review focuses on JNK and its signaling pathway, a comprehensive review of current research regarding its therapeutic effects in PD and the underlying mechanisms of exercise-mediated neuroprotection in PD management. The aim is to provide novel insights for developing PD therapeutic strategies and exploring exercise-induced effector molecules.
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