Post-Translational Modifications of Mre11 and Their Research Progress in Cancer
SHE Yuanhua, YANG Hanteng*
Mre11 is a key nuclease in the DDR (DNA damage response). And it plays a crucial role in maintaining genomic stability by regulating processes such as homologous recombination, DSB (DNA double-strand break） repair, and telomere stability. In recent years, the role of PTMs (post-translational modifications) of Mre11 in tumorigenesis and progression has garnered significant attention. This review provides a comprehensive overview of the structure and function of Mre11, as well as its major PTMs, including phosphorylation, ubiquitination and ubiquitin- like modifications, methylation, and lactylation. In various tumors, these PTMs regulate multifaceted functions of Mre11 in DNA damage response, cell cycle control, and genomic integrity, and are closely associated with chemoresistance. Furthermore, the potential of Mre11 as a therapeutic target in cancer treatment is discussed. This review aims to provide theoretical insights and novel research directions for both basic studies and clinical translation of Mre11-related therapies.
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