Research Progress of Organoids Models in Malignant Mesothelioma
YONG Sheng1,2,3, YANG Xiaotong1, CAO Wei1, MIN Weirun1, JIN Dacheng2,3, GOU Yunjiu2,3*
MM (malignant mesothelioma) is a rare cancer closely associated with asbestos exposure, characterized by poor clinical prognosis and limited research due to the scarcity of clinical cases. Traditional twodimensional cell and animal models exhibit limitations in replicating the complex biological characteristics of MM. Organoids, as emerging preclinical models, offer new insights into MM research. These are miniature cell clusters formed through in vitro three-dimensional culture, capable of self-organizing to mimic the structure and function of in vivo organs. Organoid models have been successfully applied in studies of thoracic diseases such as lung cancer, esophageal cancer, and thymic cancer, While MM organoids remain in the exploratory stage. This review summarizes the progress of organoids in MM research from three perspectives: construction methods, current applications, and challenges faced, aiming to provide reference and guidance for related studies.
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