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PPARs Signaling Pathway in Mammalian Reproduction
Yue-Chao Zhao, Zeng-Ming Yang*
College of Life Sciences, Northeast Agricultural University, Harbin 150030, China
Abstract: Peroxisome proliferator-activated receptors (PPARs) play important roles in many biological processes， including mediation of lipid metabolism， energy balance， cell differentiation and division. It has been confirmed that PPARs signaling pathway is also related to some pathological processes， such as diabetes and cancer. The understanding on PPARs has improved as the application of gene knockout technology and the artificial ligands. This article reviews PPARs expression， function and mechanism in mammalian reproductive system during the processes of ovarian cycle， luteal formation， embryo implantation， placentation and male reproduction.
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