The Role of the ECM (Extracellular Matrix) and Organoids in Skin Tissue Repair
WANG Ying, LENG Ling*
ECM (extracellular matrix) plays a regulatory role in cell function. Based on the interaction between cell and matrix, it is important to study its components and their effects on the initiation and progression of skin tissue repair. The research of ECM has promoted the development of organoid culture technology. In the microenvironment of skin organoids, the composition and structure of ECM play a key role in the growth and differentiation of skin organoids. By further studying the role of ECM in organoid regeneration and differentiation, it can provide new strategies and technical means for tissue engineering and regenerative medicine. Combined with this laboratory’s previous findings, this article will briefly review: (1) the composition/function, tissue repair mechanism of ECM, (2) its regulatory effects on the growth and differentiation of skin organoids; and (3) current research on how ECM and organoids collectively promote skin tissue repair.
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