Research Progress on Notch Signaling Pathway in Glial Cells after Ischemic Stroke
YANG Jiping1, YUAN Yuan1, LI Yujing1, LI Zheng1, GUO Tao2*, LIU Liangli3*
The occurrence of ischemic stroke is typically associated with hypoxia and disruptions in the energy metabolism of brain tissue, resulting in irreversible tissue damage and cell death. This study highlights the growing interest in the role of the Notch signaling pathway in glial cells. The Notch signaling pathway is a crucial intercellular signaling mechanism that not only plays a significant role in neurodevelopment but also is closely related to the repair processes following ischemic brain injury. Consequently, targeted therapeutic strategies aimed at the Notch signaling pathway have become a prominent area of research. This paper examines the pathophysiological mechanisms underlying ischemic stroke, along with the classification and responses of glial cells and discuss the activation process of the Notch signaling pathway in glial cells following ischemic stroke, its neuroprotective effects, therapeutic protocols, and the interconnections with related signaling pathways, providing comprehensive summaries to mitigate the detrimental effects of ischemic stroke.
CN
EN