Research Progress on the Mechanism and Clinical Significance of Ferroptosis in Preeclampsia
LIU Naiwei1, LI Jing2, YANG Qi1, HE Yue3, CUI Hongmei4*
PE (preeclampsia) is a disease that seriously threatens the health of mothers and infants during pregnancy, and its pathogenesis is complex and not fully understood. In recent years, ferroptosis, as a new type of programmed cell death, has been found to be associated with various diseases, including PE. This article reviews the mechanism of ferroptosis, including the digestion, absorption and metabolic processes of iron, the main pathways of ferroptosis (iron metabolism, lipid peroxidation, GSH-dependent antioxidant pathway) and emerging pathways (mitochondrial ROS-oxidative stress-autophagy pathway, FSP1-CoQ10-NAD(P)H pathway, etc.). At the same time, it deeply explores the role and mechanism of ferroptosis in the occurrence and development of PE, such as the abnormal iron transport in the placenta, the changes in ferroptosis-related serological indicators, and the association between oxidative stress and ferroptosis. In addition, the potential value of ferroptosis in the prediction and treatment of PE is also elaborated, including the identification of new biomarkers and the mechanism and application prospects of related drugs. Although the current research on ferroptosis and PE is still in the initial stage, clarifying mechanism of ferroptosis is of great significance for deeply understanding the pathogenesis of PE and developing effective diagnostic and treatment strategies, providing a new direction and theoretical basis for future clinical practice.
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