Regulation of Cell Apoptosis by Heat Shock Proteins

Abstract: Heat shock proteins (HSPs) were ubiquitous molecular chaperone proteins that were involved in the regulation of various physiological processes such as stress response， metabolism， proliferation and apoptosis. The mechanism of how HSP protect the cells from apoptosis was complicated， as HSP could either regulate the structure and function of several key apoptotic mediators or affect multiple apoptotic signaling pathways. Because the modulation of HSP on apoptosis depends on their capacity as chaperon proteins， blockage the chaperoning function of HSP90 has become a potential target for inducing apoptosis by anticancer drugs

CSTR: 32200.14.cjcb.2005.01.0001