Regulatory Mechanisms of Tumor Cell Death and Targeted Interventions
DENG Rong#* , ZHANG Hailiang#, ZHANG Kaiming, LI Zhiling, ZHONG Wenqing, SHAN Jialu, GUO Yiqing, LIN Fengbin, ZHU Xiaofeng*
With the in-depth study of various modes of cell death, the regulatory mechanisms governing these processes have gradually been unveiled. Notably, the immunogenicity of cell death has provided new insights into these processes, enriching the comprehension of cell death patterns. Resistance to cell death is one of the hallmarks of cancer, promoting tumorigenesis, progression, and therapeutic resistance. Targeting the induction of cell death presents a promising approach for cancer therapy, and significant progress has been made in the development of targeted drugs against core molecules involved in cell death resistance. This review focuses on the regulatory mechanisms of cell death represented by apoptosis, autophagy, ferroptosis, necroptosis, and pyroptosis, as well as their roles in tumorigenesis, metastasis, immune response, and therapeutic outcomes. This review also highlights the latest advancements in drug development targeting key molecules associated with programmed cell death resistance.
CN
EN