Genetic and Epigenetic Regulation of Drug Resistance in Tumor Therapy
ZHONG Guixiang, CHEN Jianfeng, TAN Jing*
Drug resistance is a major challenge in oncology, significantly affecting treatment efficacy and reducing patient survival. The mechanisms of resistance involve complex genetic and epigenetic variations and cover multiple treatments such as chemotherapy, targeted therapy and immunotherapy. This review examines the mechanisms of resistance to different therapies, highlighting the key role of genetic and epigenetic regulation in the formation of resistance. Recent research progress in this area is summarized. By exploring these mechanisms, the potential application in the development of novel tumor treatment strategies is considered, aiming to provide new research directions and therapeutic targets for overcoming tumor resistance.
CN
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