Research Progress of Cellular Stress in Colorectal Cancer
XU Shuidan, CAI Xiaoxia, LÜ Yongrui, WANG Fengwei*, XIE Dan*
CRC (colorectal cancer) is one of the most common malignant tumors in China, and its incidence rate is gradually rising. The high mutation rate, multiple driver genes, diverse subtypes, and high heterogeneity of CRC lead to low response rates to radiotherapy, chemotherapy, and immunotherapy, as well as poor prognosis in the late stage. Stress tolerance is an important characteristic of tumor cells as they gradually adapt to the microenvironment and maintain survival during the development of CRC. Revealing the mechanism of stress tolerance in CRC tumor cells can provide new strategies and targets for improving the effectiveness of prevention and treatment. This study reviews the role and mechanism of tumor cell stress tolerance in the pathogenesis of CRC.
CN
EN