The Development of Humanized Mouse Models and Their Applications in Hematological Research
LU Lu, ZHANG Xumiao, SONG Yuanbin*
As a preclinical animal model, humanized mice transcend species differences and immune rejection characteristics between humans and mice, and can deeply explore the pathogenesis and drug action mechanisms of diseases. They play an important role in disease mechanism research and drug evaluation. There are similarities in hematopoietic development between humans and mice, but significant differences exist in the generation and development of specific lineages, and their hematopoietic molecular regulatory mechanisms and patterns are also different. In recent years, due to the continuous innovation of gene editing and xenotransplantation technologies, humanized mice have made significant progress in the study of hematological diseases. This review covers the differences in hematopoietic development between humans and mice, the process of establishing and developing humanized mice, and the application progress in hematological diseases.
CN
EN