RNA Methylation and Chromatin Remodeling in Cancer

YE Canbin, ZHANG Jialiang, LIN Dongxin, ZHENG Jian*

(State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, China)

Abstract:

Epigenetic reprogramming plays a crucial role in the development of cancer, where the interplay between RNA m⁶A (N⁶-methyladenosine) methylation modification and chromatin remodeling has a significant impact on tumor progression. This review summarizes the interactions between m⁶A modification and chromatin remodeling, including the impact of co-transcriptional m⁶A incorporation on chromatin remodeling, how RNA m⁶A regulates chromatin status by affecting DNA methylation and histone modifications, and the regulatory role of RNA m⁶A on the three-dimensional structure of chromatin. Additionally, it discusses how chromatin remodeling can reciprocally regulate RNA m⁶A modification, including its effects on the expression and function of RNA m⁶A-related factors. These interactions play a key regulatory role in the occurrence, development, and therapeutic response of tumors.

CSTR: 32200.14.cjcb.2025.03.0007