Home > Browse Issues > Vol.47 No.3
Research Progress on Differentiation Therapy in Solid Tumors
YAN Min, LIU Qiang*
(State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Psychobehavioral Cancer Research Center, Sun Yat-sen University Cancer Center, Guangzhou 510060, China)
Abstract:
Differentiation therapy aims to induce terminally differentiation or a high differentiated state of undifferentiated or low-differentiated tumor cells, or induce transdifferentiation of tumor cells into other types of functional cells, thereby reversing the malignant phenotype of tumor cells. Since the remarkable success in the treatment of APL (acute promyelocytic leukemia), the study of differentiation therapy has rapidly expanded to other hematologic and solid tumors. This article reviews recent advances of differentiation therapy in solid tumors including regulatory mechanisms, drug development, challenges and the novel strategies.
CN
EN