Research Progress on Intratumoral Microbiota, Tumor Progression and Relevant Antitumor Strategies
FENG Senyu, LIU Na*
Trillions of microorganisms colonize various ecological niches within the human body. These microorganisms are crucial for numerous physiological activities and the maintenance of the overall health of the human. They are also closely associated with the occurrence and development of various diseases, including cancer. With advancements in microbiomic technologies, the concept of intratumoral microbiota has been gradually established. Insightful studies are currently underway to unravel the complex interactions among human body, intratumoral microbiota, and tumors. This article reviews the effects of intratumoral bacteria, fungi, and viruses on the progression of various types of cancer. It also provides a comprehensive discussion on the cutting-edge anti-tumor therapeutic strategies targeting the intratumoral microbiota. Additionally, it discusses the limitations of current research
and provides insights for future research.
CN
EN